The main road is freeway A21/E70 Torino-Piacenza, easy to reach from any point in Northern Italy.
Eastbound: Coming from Torino on the A21/E70 take the Asti-Est (east) exit and keep going on the state road SS10 towards Alessandria. Passed the village of Castello di Annone make a right turn to Nizza Monferrato/Rocchetta Tanaro. Follow signs to Cantine Marchesi Incisa.
Westbound: Coming from Alessandria/Milano/Genova on the A21/E70 take the Felizzano exit and keep going on the state road SS10 towards Asti. After 10 km / 7 miles make a left turn to Nizza Monferrato/Rocchetta Tanaro. Follow signs to Cantina Marchesi Incisa.